T3165

7-Methoxy-4-(trifluoromethyl)coumarin

≥99% (TLC)

• Synonym(s): Methyl 4-(trifluoromethyl)umbelliferyl ether
• Empirical Formula (Hill Notation): C₁₁H₇F₃O₃
• CAS Number: 575-04-2
• Molecular Weight: 244.17
• UNSPSC Code: 12352204
• NACRES: NA.32
• PubChem Substance ID: 24900113
• MDL number: MFCD00132980
• Beilstein/REAXYS Number: 225039

Properties

• Quality Segment: 200
• assay: ≥99% (TLC)
• form: powder
• solubility: acetone: 50 mg/mL, clear, colorless to faintly yellow
• fluorescence: λ_ex 333 nm; λ_em 416 nm in methanol
• SMILES string: COc1ccc2c(OC(=O)C=C2C(F)(F)F)c1
• InChI: 1S/C11H7F3O3/c1-16-6-2-3-7-8(11(12,13)14)5-10(15)17-9(7)4-6/h2-5H,1H3
• InChI key: HAZHUELNIGDYQH-UHFFFAOYSA-N

Description

Application

7-Methoxy-4-(trifluoromethyl)coumarin has been used as a substrate in cytochrome P450 2E1 (CYP2E1) activity assay and aromatase assay.

Biochem/physiol Actions

The enzymatic action of cytochrome P450 2E1 (CYP2E1) on 7-methoxy-4-(trifluoromethyl)coumarin results in a fluorescent product 7-hydroxy-4-(trifluoromethyl)coumarin (HFC) that can be measured at 409/530 nm.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Gloves