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Key Documents

SRP0439

Sigma-Aldrich

PrCP active human

recombinant, expressed in FreeStyle™ 293-F cells, ≥15% (SDS-PAGE)

Synonym(s):

HUMPCP, PCP, prolylcarboxypeptidase

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human

recombinant

expressed in FreeStyle™ 293-F cells

Assay

≥15% (SDS-PAGE)

form

aqueous solution

mol wt

53 kDa

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

concentration

0.06 mg/mL

NCBI accession no.

NM_005040

UniProt accession no.

P42785

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... PRCP(5547)

General description

Human recombinant Lysosomal Pro-X carboxypeptidase, also known as angiotensinase C (GenBank Accession No. NM_005040) amino acids 31-496 with C-terminal His-tag, MW=53 kDa, expressed in HEK293 cells.

Application

Useful for the cleavage of C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin.

Legal Information

FreeStyle is a trademark of Invitrogen Corp.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Statements

H315,H319,H360D

Hazard Classifications

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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New enzymatic route for the inactivation of angiotensin.
H Y Yang et al.
Nature, 218(5148), 1224-1226 (1968-06-29)
F Tan et al.
The Journal of biological chemistry, 268(22), 16631-16638 (1993-08-05)
Prolylcarboxypeptidase, a lysosomal serine carboxypeptidase, cleaves COOH-terminal amino acids linked to proline, as in angiotensin II and III and [des-Arg9] bradykinin. About 25% of the enzyme protein was sequenced, and the complete sequence was deduced from its human kidney cDNA.
Lin Wang et al.
American journal of obstetrics and gynecology, 195(1), 162-171 (2006-05-10)
Renin-angiotensin System is essential for the homeostasis of blood pressure in humans. The roles of renin-angiotensin system gene polymorphisms including angiotensinogen, angiotensin-converting enzyme, renin and angiotensin II receptor, type 1 genes in the pathogenesis of preeclampsia have been extensively studied
Ok Jeong Moon et al.
Advanced healthcare materials, 11(15), e2200765-e2200765 (2022-06-08)
Cancer chemotherapeutic drugs such as doxorubicin, mitomycin C, and gemcitabine, which are mostly small synthetic molecules, are still clinically useful for cancer treatment. However, despite considerable therapeutic efficacy, severe toxicity-associated problems, which are mainly caused by the non-specific mode of

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