Skip to Content
Merck
All Photos(1)

Documents

G5660

Sigma-Aldrich

Lysoganglioside-GM1 from bovine brain

≥95%, lyophilized powder

Sign Into View Organizational & Contract Pricing


About This Item

CAS Number:
MDL number:
UNSPSC Code:
12352204
NACRES:
NA.77

Quality Level

Assay

≥95%

form

lyophilized powder

storage temp.

−20°C

Related Categories

Biochem/physiol Actions

Suggested to be a modulator of cell growth and signal transduction. Accumulates in the nervous system of patients with GM1 gangliosidosis. Used for the preparation of GM1 derivatives containing different fatty acids, fluorescent tags, or other residues.

Other Notes

Gangliosides are major constituents of neuronal cell membranes and endoplasmic reticulum; contain a sialated polysaccharide chain linked to ceramide through a β-glycosidic linkage; for classification of gangliosides see Svennerholm, L., et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Tubaro, E., et al.
Eur. J. Pharmacol. Environ. Toxicol. Pharmacol. Soc., 248, 175-175 (1993)
T Kobayashi et al.
Journal of neurochemistry, 59(4), 1452-1458 (1992-10-01)
By using a sensitive method, we assayed lysocompounds of gangliosides and asialogangliosides in tissues from four patients with GM2 gangliosidosis (one with Sandhoff disease and three with Tay-Sachs disease) and from three patients with GM1 gangliosidosis [one with infantile type
Y A Hannun et al.
Science (New York, N.Y.), 235(4789), 670-674 (1987-02-06)
Lysosphingolipids potently and reversibly inhibited protein kinase C activity and binding of phorbol dibutyrate in vitro and in human platelets. As with activation of protein kinase C by phosphatidylserine and sn-1,2-diacylglycerol, inhibition was subject to surface dilution. Accordingly, inhibition in
A Kharlamov et al.
Proceedings of the National Academy of Sciences of the United States of America, 91(14), 6303-6307 (1994-07-05)
A bilateral photochemically induced thrombotic lesion of rat sensorimotor cortex (approximately 3 mm in diameter and 25 mm3 in volume) is associated with a persistent cognition (learning and memory) deficit, which was evaluated with water maze tasks. The N-dichloroacetylsphingosine derivative
R T Huang et al.
FEBS letters, 281(1-2), 39-42 (1991-04-09)
Fluorescent dansyl derivatives of 3 natural sphingolipids (gangliosides, cerebroside and sphingomyelin) were shown to be readily taken up by culture cells (HeLa-, MDCK- and primary rat brain cells). A part of the incorporated fluorescent sphingolipids remained associated with the cells

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service