900667

Acetonitrile

≥99.92%, suitable for mass spectrometry (MS), UHPLC

• Synonym(s): ACN, Cyanomethane, Ethyl nitrile, Methyl cyanide
• Linear Formula: CH₃CN
• CAS Number: 75-05-8
• Molecular Weight: 41.05
• Beilstein: 741857
• EC Number: 200-835-2
• MDL number: MFCD00001878
• UNSPSC Code: 12191502
• NACRES: NA.21
• grade: HPLC grade
• technique(s): mass spectrometry (MS): suitable
• application(s): PFAS testing; food and beverages
• bp: 81-82 °C (lit.)
• vapor pressure: 72.8 mmHg ( 20 °C)

Properties

• Product Name: Acetonitrile, for UHPLC, suitable for mass spectrometry (MS)
• grade: HPLC grade
• Quality Level: 100
• Agency: suitable for ASTM^® 7968; suitable for ASTM^® 7979; suitable for DIN 38407-42; suitable for EPA 1633; suitable for EPA 8327; suitable for GB 31604.35-2016; suitable for GB 5009.253-2016; suitable for ISO 21675 2019
• reg. compliance: suitable for FDA C-010.02
• vapor density: 1.41 (vs air)
• vapor pressure: 72.8 mmHg ( 20 °C)
• Assay: ≥99.92%
• form: liquid
• autoignition temp.: 973 °F
• expl. lim.: 16 %
• technique(s): mass spectrometry (MS): suitable
• refractive index: n20/D 1.344 (lit.)
• bp: 81-82 °C (lit.)
• mp: −45 °C (lit.)
• density: 0.786 g/mL at 25 °C (lit.)
• SMILES string: CC#N
• application(s): PFAS testing; food and beverages
• format: neat
• InChI: 1S/C2H3N/c1-2-3/h1H3
• InChI key: WEVYAHXRMPXWCK-UHFFFAOYSA-N

Description

General description

Acetonitrile, an aliphatic nitrile, is a highly volatile, aprotic polar organic solvent that finds wide use in analytical determinations. It is UV-transparent − a property that facilitates its utilization in spectrophotometric and fluorimetric analyses. Its low viscosity, high elution strength and miscibility in water makes it viable in many chromatography systems.
Its other applications include its use as a mobile phase additive and as an extraction solvent in liquid-liquid extraction (LLC), solid-phase extraction (SPE) and microextraction for chromatographic applications, etc.[1]

Application

Acetonitrile may be used:

• As an extraction solvent for the quantification of pesticide analytes in foodstuffs[2][3] and tea,[4] industrial dyes in juice and wine[5] by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS).
• As an organic modifier in the determination of bisphenol A-diglycidyl ether, bisphenol F-diglycidyl ether and their derivatives in canned food and beverages by fast LC–MS/MS.[6]

Acetonitrile, an organic solvent, is used as a mobile phase/extraction solvent in the ultra-high performance liquid chromatorgraphy − tandem mass spectrometry (UHPLC-MS) analysis of pesticides in tobacco samples.[7] It can be potentially used with a reverse-phase column to determine the concentration of diclofenac (DCF).[8]

Legal Information

ASTM is a registered trademark of American Society for Testing and Materials

Safety Information

• Pictograms: GHS02,GHS07
• Signal Word: Danger
• Hazard Statements: H225,H302 + H312 + H332,H319
• Precautionary Statements: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point(F): 35.6 °F - closed cup
• Flash Point(C): 2.0 °C - closed cup