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Peroxynitrite

Name: Peroxynitrite
Brand: MM

liquid, biological oxidizing agent, Calbiochem^®

Synonym(s):

Nitroxyl anion, Peroxynitrous acid

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About This Item

UNSPSC Code:

51111800

NACRES:

NA.77

Form:

liquid

Storage condition:

OK to freeze, avoid repeated freeze/thaw cycles, protect from light

Pricing and availability is not currently available.

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Properties

Product Name

Peroxynitrite, Synthesized from isoamyl nitrite and hydrogen peroxide.

Quality Segment

100

form

liquid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, avoid repeated freeze/thaw cycles, protect from light

color

yellow

solubility

soluble (Peroxynitrite is soluble in aqueous buffers that have been pre-purged with an inert gas and pre-cooled to 4°C.)

shipped in

dry ice

storage temp.

−70°C

Description

General description

Note: 1 set = 2 x 1 ml.

Synthesized from isoamyl nitrite and hydrogen peroxide. Peroxynitrite (ONOO–) is a strong biological oxidizing agent that reacts with DNA, membrane phospholipids, sulfhydryl groups, and tyrosine. It has been implicated in a variety of patho-physiological conditions including acute respiratory distress syndrome (ARDS), arthritis, atherosclerosis, inflammatory bowel disease, ischemia-reperfusion, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity, and septic shock. This product decomposes or isomerizes at pH 8 or less; the half-life at pH 7.5 is ~1.5 s. ε^{302 nm} = 1670^M-1cm^-1 in 0.1 MNaOH.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Oxidizing agent that reacts with DNA, membrane phospholipids, sulfhydryl groups, and tyrosine

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Physical form

Supplied in 4.7% NaOH at 160-200 mM.

Preparation Note

Peroxynitrite is soluble in aqueous buffers that have been pre-purged with an inert gas and pre-cooled to 4°C.

Protect from heat, light, metal ions, and air. Peroxynitrite is unstable; thaw rapidly, dispense into aliquots, purge tubes with an inert gas, and freeze -70°C. Activity decreases ~2% /day at -20°C.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Marla, S.S., et al. 1997. Proc. Natl. Acad. Sci. USA94, 14243.
Sakuma, S., et al. 1997. Biochem. Biophys. Res. Commun. 230, 476.
Lymar, S.V., et al. 1996. Biochemistry 35, 7855.
Uppu, R.M., and Pryor, W.A. 1996. Methods Enzymol. 269, 322.
Ischiropoulos, H., and al-Medhi, A.B. 1995. FEBS Lett. 364, 279.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Oxidizer (K)

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This Item	475870	217386	584223
Sigma-Aldrich 516620 Peroxynitrite	Sigma-Aldrich 475870 MnTBAP	Sigma-Aldrich 217386 Carboxy-PTIO, Sodium Salt	Sigma-Aldrich 584223 Tetrahydrouridine
description Synthesized from isoamyl nitrite and hydrogen peroxide.	description Cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger.	description Reacts with nitric oxide at pH 7.4, resulting in the generation of NO2⁻/NO3⁻ with a rate constant of 1 x 10⁴ M⁻¹sec⁻¹.	description InSolution, ≥90%, competitive inhibitor of cytidine deaminase
form liquid	form solid	form solid	form liquid
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. −70°C	storage temp. −20°C	storage temp. −20°C	storage temp. −70°C
solubility soluble (Peroxynitrite is soluble in aqueous buffers that have been pre-purged with an inert gas and pre-cooled to 4°C.)	solubility aqueous base: soluble	solubility HEPES Buffer: 0.4 mg/mL	solubility -
storage condition OK to freeze, protect from light, avoid repeated freeze/thaw cycles	storage condition OK to freeze, protect from light, desiccated	storage condition OK to freeze, protect from light, desiccated (hygroscopic)	storage condition OK to freeze, protect from light, avoid repeated freeze/thaw cycles

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Pictograms

GHS08,GHS05

Signal Word

Danger

Hazard Codes

H290,H314,H341,H351

Precautionary Statements

P202 - P234 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338

Hazard Classifications

Carc. 2 - Eye Dam. 1 - Met. Corr. 1 - Muta. 2 - Skin Corr. 1B

Storage Class

5.1B - Oxidizing hazardous materials

WGK

WGK 2

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