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M-123

Supelco

Metoprolol tartrate solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C15H25NO3 · 0.5 C4H6O6
CAS Number:
56392-17-7
Molecular Weight:
342.41
EC Number:
200-659-6
MDL number:
MFCD23141017
UNSPSC Code:
41116107
PubChem Substance ID:
329817863
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol (as free base)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

2-8°C

SMILES string

CC(C)NCC(COC1=CC=C(CCOC)C=C1)O.CC(C)NCC(COC2=CC=C(CCOC)C=C2)O.OC(C(O)=O)C(C(O)=O)O

InChI

1S/2C15H25NO3.C4H6O6/c2*1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3;5-1(3(7)8)2(6)4(9)10/h2*4-7,12,14,16-17H,8-11H2,1-3H3;1-2,5-6H,(H,7,8)(H,9,10)

InChI key

YGULWPYYGQCFMP-UHFFFAOYSA-N

Gene Information

human ... ADRB1(153)

Related Categories

General description

A certified solution standard applicable for use in clinical toxicology or forensic analysis by LC-MS/MS or GC/MS. Metoprolol is used for the treatment of multiple heart conditions including hypertension, angina, and tachycardia. This beta blocker is sold under the trade names Lepressor and Toprol XL®.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
Toprol XL is a registered trademark of Astrazeneca AB

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes,Central nervous system

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Metoprolol Tartrate Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1076

Metoprolol Tartrate

Atenolol ≥98% (TLC), powder

Sigma-Aldrich

A7655

Atenolol

Angela Price et al.
Hypertension (Dallas, Tex. : 1979), 61(6), 1263-1269 (2013-04-03)
In young healthy humans, sympathetic vasoconstriction is markedly blunted during exercise to optimize blood flow to the metabolically active muscle. This phenomenon known as functional sympatholysis is impaired in hypertensive humans and rats by angiotensin II-dependent mechanisms, involving oxidative stress
Chirayu Vyas et al.
Acute cardiac care, 14(4), 117-119 (2012-12-12)
We report a patient who presented with takotsubo cardiomyopathy but was misdiagnosed as an anterior wall ST elevation myocardial infarction (AWMI). We illustrate how misdiagnosis led to mismanagement by initiating intravenous inotropic agents that led to further hemodynamic compromise. Subsequent
B Sasko et al.
Deutsche medizinische Wochenschrift (1946), 137(50), 2637-2640 (2012-12-12)
A 70-year-old woman was admitted to hospital with progressive chest pain. Coronary angiography demonstrated a significant stenosis of the left descending artery (LAD), which was treated by percutaneous coronary intervention (PCI) and stent implantation. During this intervention, a coronary perforation
Abdulhakim A A Khaled et al.
Acta poloniae pharmaceutica, 70(4), 743-747 (2013-08-08)
This study was aimed to develop level A, B and C in vitro-in vivo correlation (IVIVC) for encapsulated metoprolol tartrate (T1, T2 and T3 having metoprolol tartrate/polymer ratio of 1: 1, 1: 1.5 and 1: 2,w/w). The in vitro data
Yunhui Du et al.
PloS one, 7(12), e52911-e52911 (2013-01-10)
Autoantibodies against the second extracellular loop of the β(1)-adrenergic receptor (β(1)-AA) not only contribute to increased susceptibility to heart failure, but also play a causative role in myocardial remodeling through their sympathomimetic-like effects that are induced upon binding to the
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