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Sigma-Aldrich

Dichloro(1,2-diaminocyclohexane)platinum(II)

Synonym(s):

(1,2-Diaminocyclohexane)platinum(II) chloride

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About This Item

Linear Formula:
[C6H10(NH2)2]PtCl2
CAS Number:
52691-24-4
Molecular Weight:
380.17
MDL number:
MFCD00058826
UNSPSC Code:
12161600
PubChem Substance ID:
24865237
NACRES:
NA.22

Quality Level

100

reaction suitability

core: platinum
reagent type: catalyst

mp

280 °C (dec.) (lit.)

SMILES string

Cl[Pt]Cl.NC1CCCCC1N

InChI

1S/C6H14N2.2ClH.Pt/c7-5-3-1-2-4-6(5)8;;;/h5-6H,1-4,7-8H2;2*1H;/q;;;+2/p-2

InChI key

PNNCIXRVXCLADM-UHFFFAOYSA-L

Pictograms

Health hazardCorrosion
GHS08,GHS05

Signal Word

Danger

Hazard Classifications

Carc. 2 - Eye Dam. 1 - Lact. - Muta. 2 - Repr. 1B - Resp. Sens. 1B - Skin Sens. 1 - STOT RE 1

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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G R Gibbons et al.
Cancer research, 49(6), 1402-1407 (1989-03-15)
Tetrachloro(D,L-trans)1,2-diaminocyclohexaneplatinum(IV) (tetraplatin) is a new platinum analogue which is less nephrotoxic than cisplatin and is effective in some cell lines which have become resistant to cisplatin. Since platinum(IV) compounds are thought to require reduction to their platinum(II) analogues for activity
V Boudný et al.
Nucleic acids research, 20(2), 267-272 (1992-01-25)
Modification of DNA and double-stranded deoxyoligonucleotides with antitumour 1,2-diamino-cyclohexanedinitroplatinum(II) (Pt-dach) complexes was investigated with the aid of physico-chemical methods and chemical probes of nucleic acid conformation. The three Pt-dach complexes were used which differed in isomeric forms of the dach
P F Carfagna et al.
Cancer chemotherapy and pharmacology, 27(5), 335-341 (1991-01-01)
Plasma biotransformations of tetrachloro(d,l-trans)1,2-diaminocyclohexaneplatinum(IV) (tetraplatin) were determined in vivo at both therapeutic (3 mg/kg) and toxic (12 mg/kg) doses in Fischer 344 rats. Tetraplatin was rapidly converted to dichloro(d,l-trans)1,2-diaminocyclohexaneplatinum(II) [PtCl2(dach)]. This conversion was complete at the earliest time measured (7.5
Y Ohya et al.
Journal of biomaterials science. Polymer edition, 7(12), 1085-1096 (1996-01-01)
cis-Dichloro(cyclohexane-trans-l-1,2-diamine)platinum(II) (Dach-Pt(chlorato)), is a platinum complex which is expected to exhibit higher antitumor activity than, and show no cross resistance with, cisplatin. However, its strong side-effects and low water-solubility have also been cited. We report that polymer/antitumor drug conjugates shows
X Zhai et al.
Biochemistry, 37(46), 16307-16315 (1998-11-18)
Several eukaryotic cellular proteins recognize DNA modified by the anticancer drug cisplatin (cis-diamminedichloroplatinum(II) or cis-DDP); among these proteins is a class of DNA-binding molecules containing the HMG (high-mobility group) box DNA recognition motif. We have previously reported the extraordinarily high
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