Different protein kinase C isoenzymes mediate inhibition of cardiac rapidly activating delayed rectifier K

Elevated angiotensin II (Ang II) and sympathetic activity contributes to a high risk of ventricular arrhythmias in heart disease. The rapidly activating delayed rectifier K The whole-cell patch-clamp technique was used to record I A broad spectrum PKC inhibitor Gö6983 (not inhibiting PKCε), a selective cPKC inhibitor Gö6976 and a PKCα-specific inhibitor peptide, blocked the inhibition of I Our results indicated that inhibition of I