- Optimization of methotrexate loaded niosomes by Box-Behnken design: an understanding of solvent effect and formulation variability.
Optimization of methotrexate loaded niosomes by Box-Behnken design: an understanding of solvent effect and formulation variability.
Drug development and industrial pharmacy (2017-04-20)
Ahmed S Zidan, Mahmoud Mokhtar Ibrahim, Nagia A El Megrab
PMID28420295
摘要
Dermal drug delivery system which localizes methotrexate (MTX) in the skin is advantageous in topical treatment of psoriasis. The aim of the current study was to understand dilution effects and formulation variability for the potential formation of niosomes from proniosome gels of MTX. Box-Behnken's design was employed to prepare a series of MTX proniosome gels of Span 40, cholesterol (Chol-X
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