- Cdc2-like kinase 2 in the hypothalamus is necessary to maintain energy homeostasis.
Cdc2-like kinase 2 in the hypothalamus is necessary to maintain energy homeostasis.
International journal of obesity (2005) (2016-10-14)
P G F Quaresma, L Weissmann, T M Zanotto, A C Santos, A H B de Matos, I C Furigo, F M Simabuco, J Donato, J C Bittencourt, I Lopes-Cendes, P O Prada
PMID27733761
摘要
To investigate whether the Cdc2-like kinase 2 (CLK2) is expressed in hypothalamic neurons and if it is, whether the hypothalamic CLK2 has a role in the regulation of energy balance. Swiss mice on chow or high-fat diet (HFD) and db/db mice on chow diet were used to address the role of CLK2 in the hypothalamus. Hypothalamic CLK2 Thus, our results suggest that protein CLK2 integrates some important hypothalamic pathways, and may be a promising molecule for new therapeutic approaches for obesity and diabetes.
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