- KDM3A coordinates actin dynamics with intraflagellar transport to regulate cilia stability.
KDM3A coordinates actin dynamics with intraflagellar transport to regulate cilia stability.
The Journal of cell biology (2017-03-02)
Patricia L Yeyati, Rachel Schiller, Girish Mali, Ioannis Kasioulis, Akane Kawamura, Ian R Adams, Christopher Playfoot, Nick Gilbert, Veronica van Heyningen, Jimi Wills, Alex von Kriegsheim, Andrew Finch, Juro Sakai, Christopher J Schofield, Ian J Jackson, Pleasantine Mill
PMID28246120
摘要
Cilia assembly and disassembly are coupled to actin dynamics, ensuring a coherent cellular response during environmental change. How these processes are integrated remains undefined. The histone lysine demethylase KDM3A plays important roles in organismal homeostasis. Loss-of-function mouse models of