- Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation.
Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation.
European journal of medicinal chemistry (2016-09-07)
Fadi Soukarieh, Matthew W Nowicki, Amandine Bastide, Tuija Pöyry, Carolyn Jones, Kate Dudek, Geetanjali Patwardhan, François Meullenet, Neil J Oldham, Malcolm D Walkinshaw, Anne E Willis, Peter M Fischer
PMID27592390
摘要
Eukaryotic translation initiation factor 4E (eIF4E) is considered as the corner stone in the cap-dependent translation initiation machinery. Its role is to recruit mRNA to the ribosome through recognition of the 5'-terminal mRNA cap structure (m