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Merck
  • Septin 9 induces lipid droplets growth by a phosphatidylinositol-5-phosphate and microtubule-dependent mechanism hijacked by HCV.

Septin 9 induces lipid droplets growth by a phosphatidylinositol-5-phosphate and microtubule-dependent mechanism hijacked by HCV.

Nature communications (2016-07-16)
Abdellah Akil, Juan Peng, Mohyeddine Omrane, Claire Gondeau, Christophe Desterke, Mickaël Marin, Hélène Tronchère, Cyntia Taveneau, Sokhavuth Sar, Philippe Briolotti, Soumaya Benjelloun, Abdelaziz Benjouad, Patrick Maurel, Valérie Thiers, Stéphane Bressanelli, Didier Samuel, Christian Bréchot, Ama Gassama-Diagne
摘要

The accumulation of lipid droplets (LD) is frequently observed in hepatitis C virus (HCV) infection and represents an important risk factor for the development of liver steatosis and cirrhosis. The mechanisms of LD biogenesis and growth remain open questions. Here, transcriptome analysis reveals a significant upregulation of septin 9 in HCV-induced cirrhosis compared with the normal liver. HCV infection increases septin 9 expression and induces its assembly into filaments. Septin 9 regulates LD growth and perinuclear accumulation in a manner dependent on dynamic microtubules. The effects of septin 9 on LDs are also dependent on binding to PtdIns5P, which, in turn, controls the formation of septin 9 filaments and its interaction with microtubules. This previously undescribed cooperation between PtdIns5P and septin 9 regulates oleate-induced accumulation of LDs. Overall, our data offer a novel route for LD growth through the involvement of a septin 9/PtdIns5P signalling pathway.

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白蛋白,牛血清,组分V,不含脂肪酸
Sigma-Aldrich
单克隆抗 β-微管蛋白抗体 小鼠抗, clone TUB 2.1, ascites fluid