- Dibenzazepines and dibenzoxazepines as sodium channel blockers.
Dibenzazepines and dibenzoxazepines as sodium channel blockers.
Bioorganic & medicinal chemistry letters (2014-12-04)
Stephen M Lynch, Laykea Tafesse, Kevin Carlin, Parijat Ghatak, Donald J Kyle
PMID25466191
摘要
We have identified two related series of dibenzazepine and dibenzoxazepine sodium channel blockers, which showed good potency on Nav1.7 in FLIPR-based and electrophysiological functional assays.