- Aerobic ruthenium-catalyzed oxidative cyanation of tertiary amines with sodium cyanide.
Aerobic ruthenium-catalyzed oxidative cyanation of tertiary amines with sodium cyanide.
Journal of the American Chemical Society (2003-12-11)
Shun-Ichi Murahashi, Naruyoshi Komiya, Hiroyuki Terai, Takahiro Nakae
PMID14664574
摘要
RuCl3-catalyzed oxidative cyanation of tertiary amines with sodium cyanide under molecular oxygen (1 atm) at 60 degrees C gives the corresponding alpha-aminonitriles, which are versatile synthetic intermediates of various compounds such as amino acids and unsymmetrical 1,2-diamines, in excellent yields. This reaction is clean and should be an environmentally benign and useful process.
材料