- A microwave radiosynthesis of the 4-[18F]-fluorobenzyltriphenylphosphonium ion.
A microwave radiosynthesis of the 4-[18F]-fluorobenzyltriphenylphosphonium ion.
Journal of labelled compounds & radiopharmaceuticals (2014-10-21)
Hayden T Ravert, Daniel P Holt, Robert F Dannals
PMID25329827
摘要
The 4-[(18)F]-fluorobenzyltriphenylphosphonium cation was synthesized by a series of microwave reactions from no carrier added [(18)F]-fluoride. The microwave procedure reduced the quantity of reagents used and synthesis time when compared with the original synthesis. In addition, problematic solid phase extraction, sodium borohydride reduction by column and inconsistent yields with excessive precipitate formation during the bromination step were eliminated. The 4-[(18)F]-fluorobenzyltriphenylphosphonium cation was produced radiochemically pure in 8.3% yield with a specific radioactivity of 534.5 ± 371.4 GBq/µmole at end of synthesis.
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酒精, purum, absolute ethanol, denaturated with 4.8% isopropanol, A15 IPA1, ≥99.8% (based on denaturant-free substance)
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酒精, BioUltra, for molecular biology, ≥99.8%, (absolute alcohol, without additive, A15 o1)
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酒精, purum, fine spirit, denaturated with 4.8% methanol, F25 METHYL1, ~96% (based on denaturant-free substance)
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酒精, purum, absolute ethanol, denaturated with 2% 2-butanone, A15 MEK1, ≥99.8% (based on denaturant-free substance)
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酒精, purum, fine spirit, denaturated with 2% 2-butanone, F25 MEK1, ~96% (based on denaturant-free substance)