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Merck
  • Repair of the donor areas defects after split-thickness skin grafts utilizing an advanced epithelialization dressing.

Repair of the donor areas defects after split-thickness skin grafts utilizing an advanced epithelialization dressing.

The Journal of dermatological treatment (2012-12-12)
Pier Alessandro Fanti, Emi Dika, Sabina Vaccari, Cosimo Misciali, Alma Ismaili, Alessia Barisani, Annalisa Patrizi
摘要

The management of surgical wounds of the donor areas for split-thickness skin grafts might be difficult in terms of pain, risk of infection, and delayed healing. In the period from September 2011 to June 2012, 12 patients affected by large ulcerated basal cell carcinoma (BCC) of the lower legs, 2 patients affected by squamous cell carcinoma (SCC), and 1 patient presenting malignant melanoma located on the scalp, with split-thickness skin grafts were treated. In the 12 BCC patients, the donor site areas were situated on the anterior or lateral site of the contralateral thigh and in 3 other patients on the forearms. Immediately after dermatome skin removal of 0.3 mm layer of epidermis, the donor sites were treated by applying an advanced epithelialization dressing consisting of pure cellulose film in all patients. The wound surfaces were covered by the cellulose dressing with 1 cm of excess. Bleeding was controlled with slight compression with sterile gauzes before the medication was applied. Multiple small cuts of the cellulose dressing, with a No. 11 surgical blade were made, in order to avoid hematoma formation or fluid accumulation. A mild compression bandage was used in all patients. The patients were visited after 7, 14, and 21 days. The bandage was removed after 1 week and the medical device was left at the site for other 7 days. After 2 weeks, the medical device was partially detached on the underlying areas showing almost completely reepithelialization. Almost no pain was referred by the patients. In the authors' experience, this medical device markedly reduces the level of pain especially at the time of dressing application, after the surgical procedure, and during the healing process. No infections were observed. The healing process was fast and produced good aesthetic results. The use of Cuticell® Epigraft BSN medical device simplifies the management and healing of the donor areas for split-thickness skin grafts.

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Sigma-Aldrich
纤维素, microcrystalline, powder, 20 μm
Sigma-Aldrich
纤维素, microcrystalline, powder
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纤维素, fibers, (medium)
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Sigmacell 纤维素, Type 20, 20 μm
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α纤维素, powder
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纤维素, colloidal, microcrystalline
Supelco
Avicel® PH-101, ~50 μm particle size
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Sigmacell 纤维素, Type 101, Highly purified, fibers
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Sigmacell 纤维素, Type 50, 50 μm
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α纤维素, BioReagent, suitable for insect cell culture
Sigma-Aldrich
Avicel® PH-101, tested according to Ph. Eur.
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纤维素, powder, for column chromatography
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纤维素, DS-0, powder, suitable for thin layer chromatography (TLC)
Supelco
纤维素, acid washed, powder, for column chromatography
Supelco
纤维素, DFS-0, microcrystalline, suitable for thin layer chromatography (TLC)
Supelco
纤维素, acid washed, from spruce, for column chromatography