- Synthesis of alpha,alpha-dibromo esters as precursors of ynolates.
Synthesis of alpha,alpha-dibromo esters as precursors of ynolates.
Chemical & pharmaceutical bulletin (2003-04-04)
Mitsuru Shindo, Yusuke Sato, Ryoko Koretsune, Takashi Yoshikawa, Kenji Matsumoto, Kotaro Itoh, Kozo Shishido
PMID12673013
摘要
Aliphatic alpha,alpha-dibromo esters, precursors of ynolates, were synthesized via bromination of lithium alpha-bromo ester enolates with 1,2-dibromotetrafluoroethane in good yields. alpha-Trimethylsilyl-alpha,alpha-dibromo esters were synthesized via radical bromination.