Conversion of pyridine to imidazo[1,2-a]pyridines by copper-catalyzed aerobic dehydrogenative cyclization with oxime esters.

Conversion of pyridine to imidazo[1,2-a]pyridines by copper-catalyzed aerobic dehydrogenative cyclization with oxime esters.

Organic letters (2013-11-23)

Huawen Huang, Xiaochen Ji, Xiaodong Tang, Min Zhang, Xianwei Li, Huanfeng Jiang

摘要

A rapid and environmentally friendly conversion of pyridine to imidazo[1,2-a]pyridines has been developed via copper-catalyzed aerobic dehydrogenative cyclization with ketone oxime esters.

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360570

Sigma-Aldrich

吡啶, ACS reagent, ≥99.0%

270407

Sigma-Aldrich

吡啶, suitable for HPLC, ≥99.9%

P57506

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吡啶, ReagentPlus^®, ≥99%

270970

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吡啶, anhydrous, 99.8%

203122

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铜, powder, 99.999% trace metals basis

349178

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774111

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铜, nanopowder, 40-60 nm particle size (SAXS), ≥99.5% trace metals basis

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吡啶, ACS reagent, ≥99.0%

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吡啶, ≥99%

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Supelco

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