- Synthesis and pharmacological evaluation of a new class of peroxisome proliferator-activated receptor modulators.
Synthesis and pharmacological evaluation of a new class of peroxisome proliferator-activated receptor modulators.
Bioorganic & medicinal chemistry letters (2002-11-22)
Markus Thor, Katarina Beierlein, Graeme Dykes, Anna Lena Gustavsson, Jessica Heidrich, Lena Jendeberg, Bengt Lindqvist, Cecile Pegurier, Patrick Roussel, Martin Slater, Stefan Svensson, Mona Sydow-Bäckman, Ulla Thornström, Jonas Uppenberg
PMID12443777
摘要
A series of 5-substituted 2-benzoylaminobenzoic acids has been synthesized and assayed for PPARalpha/gamma activity. Both dual activators and selective PPARgamma agonists have been identified. This class of compounds was shown to activate the PPARgamma receptor through interaction with a novel binding site.