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Merck
  • Effects of drug and chemical pretreatments on biliary excretion of phenylcyclohexene in the rat.

Effects of drug and chemical pretreatments on biliary excretion of phenylcyclohexene in the rat.

Drug and chemical toxicology (1984-01-01)
F C Law, S Chakrabarti
摘要

The biliary excretion of 14C-phenylcyclohexene and its metabolites were studied in rats pretreated with an inducer or inhibitor of mixed-function oxidases or with an agent known to deplete liver glutathione. Pretreatment of rats with 3-methylcholanthrene or phenobarbital enhanced the biliary excretion of 14C-phenylcyclohexene and/or its metabolites. Conversely, pretreatment of rats with SKF-525A or piperonyl butoxide decreased the biliary excretion of 14C-phenylcyclohexene and/or its metabolites. In contrast, pretreatment of rats with diethylmaleate did not alter significantly the rate of biliary excretion of radioactivity.

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Sigma-Aldrich
1-苯基-1-环己烯, 95%