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Merck
  • Organocatalytic highly enantioselective synthesis of secondary alpha-hydroxyphosphonates.

Organocatalytic highly enantioselective synthesis of secondary alpha-hydroxyphosphonates.

Organic letters (2006-10-06)
Rajasekhar Dodda, Cong-Gui Zhao
摘要

[reaction: see text] The first organocatalytic cross aldol reaction of ketones and diethyl formylphosphonate hydrate has been realized by using readily available l-prolinamide as the catalyst. Secondary alpha-hydroxyphosphonates have been synthesized in high enantioselective (up to >99% ee) and good diastereoselectivity.

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Sigma-Aldrich
L-脯氨酰胺, 98%