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Merck
  • In vitro activity of the chelating agents nitroxoline and oxine against Mycobacterium bovis BCG.

In vitro activity of the chelating agents nitroxoline and oxine against Mycobacterium bovis BCG.

International journal of antimicrobial agents (2001-12-12)
B Murugasu-Oei, T Dick
摘要

The chelating antibiotic nitroxoline (5-nitro-8-hydroxyquinoline) showed a bacteriostatic effect at a concentration of 10 microM for Mycobacterium bovis BCG. At higher concentrations the compound showed moderate cidal activity against growing bacilli. In contrast, its non-nitrated derivative oxine (8-hydroxyquinoline, MIC=2 microM) reduced the viability of a growing culture rapidly, 5000-fold at a concentration where the nitroxoline was merely bacteriostatic. Both compounds showed appreciable cidal activity against bacilli in their hypoxic dormant state.

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Sigma-Aldrich
8-羟基-5-硝基喹啉, 96%