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Merck
  • Alterations in serum immunoglobulin levels in workers occupationally exposed to trichloroethylene.

Alterations in serum immunoglobulin levels in workers occupationally exposed to trichloroethylene.

Carcinogenesis (2013-01-02)
Luoping Zhang, Bryan A Bassig, Joseph L Mora, Roel Vermeulen, Yichen Ge, John D Curry, Wei Hu, Min Shen, Chuangyi Qiu, Zhiying Ji, Boris Reiss, Cliona M McHale, Songwang Liu, Weihong Guo, Mark P Purdue, Fei Yue, Laiyu Li, Martyn T Smith, Hanlin Huang, Xiaojiang Tang, Nathaniel Rothman, Qing Lan
摘要

Trichloroethylene (TCE) has been associated with a variety of immunotoxic effects and may be associated with an increased risk of non-Hodgkin lymphoma (NHL). Altered serum immunoglobulin (Ig) levels have been reported in NHL patients and in animals exposed to TCE. Recently, we reported that occupational exposure to TCE is associated with immunosuppressive effects and immune dysfunction, including suppression of B-cell counts and activation, even at relatively low levels. We hypothesized that TCE exposure would also affect Ig levels in humans. We measured serum levels of IgG, IgM and IgE, by enzyme-linked immunosorbent assay, in TCE-exposed workers (n = 80) and unexposed controls (n = 45), matched by age and gender, in a cross-sectional, molecular epidemiology study of occupational exposure to TCE in Guangdong, China. Exposed workers had about a 17.5% decline in serum levels of IgG compared with unexposed controls (P = 0.0002). Similarly, serum levels of IgM were reduced by about 38% in workers exposed to TCE compared with unexposed controls (P < 0.0001). Serum levels of both IgG and IgM were significantly decreased in workers exposed to TCE levels below 12 p.p.m., the median exposure level. Adjustment for B-cell counts had minimal impact on our findings. IgE levels were not significantly different between exposed and control subjects. These results provide further evidence that TCE is immunotoxic at relatively low exposure levels and provide additional biologic plausibility for the reported association of TCE with NHL.

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三氯乙烯, ACS reagent, ≥99.5%
Supelco
三氯乙烯, analytical standard, stabilized with 30 – 50 ppm Diisopropylamine
Supelco
三氯乙烯 溶液, certified reference material, 5000 μg/mL in methanol
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三氯乙烯, anhydrous, contains 40 ppm diisopropylamine as stabilizer, ≥99%
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三氯乙烯, ≥99%