Azobisisobutyronitrile initiated aerobic oxidative transformation of amines: coupling of primary amines and cyanation of tertiary amines.

Azobisisobutyronitrile initiated aerobic oxidative transformation of amines: coupling of primary amines and cyanation of tertiary amines.

Organic letters (2012-10-31)

Lianghui Liu, Zikuan Wang, Xuefeng Fu, Chun-Hua Yan

摘要

In the presence of a catalytic amount of radical initiator AIBN, primary amines are oxidatively coupled to imines and tertiary amines are cyanated to α-aminonitriles. These "metal-free" aerobic oxidative coupling reactions may find applications in a wide range of "green" oxidation chemistry.

材料

產品編號

品牌

產品描述

441090

Sigma-Aldrich

2,2′-偶氮(2-甲基丙腈), 98%

768375

Sigma-Aldrich

偶氮二异丁腈, 12 wt. % in acetone

755745

Sigma-Aldrich

2,2′-偶氮(2-甲基丙腈), recrystallized from methanol, 99%

714887

Sigma-Aldrich

2,2′-偶氮(2-甲基丙腈) 溶液, 0.2 M in toluene

11630

Sigma-Aldrich

2,2′-偶氮(2-甲基丙腈), purum, ≥98.0% (GC)