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  • [Role of actin microfilaments in depression of acetylcholine-induced current in Helix lucorum neurons on cellular analogue of habituation].

[Role of actin microfilaments in depression of acetylcholine-induced current in Helix lucorum neurons on cellular analogue of habituation].

Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova (2012-06-14)
A S Pivovarov, N A Vasil'eva, G B Murzina, D A Makhnovskiĭ
摘要

Toxins that impair the function of actin microfilaments in cytoskeleton, cytochalasin B (disrupts microfilaments by inhibiting actin polymerization) and phalloidin (binds polymeric F-actin, stabilizing it and interfering with the function of actin-rich structures) reduce the depression of acetylcholine-induced inward current in Helix lucorum command neurons of defensive behavior during rhythmical local acetylcholine applications to soma (cellular analogue of habituation). These results and mathematical simulation allow us to suggest that the depression of cholinosensitivity of extrasynaptic membrane zones in command neurons on the cellular analogue of habituation is associated with the involvement of actin microfilaments in reduction of the number of membrane cholinoreceptors.

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Sigma-Aldrich
细胞松弛素B 来源于Drechslera dematioidea, ≥98% (HPLC), powder
Sigma-Aldrich
细胞松弛素B 来源于Drechslera dematioidea, Ready Made Solution, 10 mg/mL in DMSO
Sigma-Aldrich
鬼笔环肽 来源于鬼笔鹅膏, ≥90%