跳轉至內容
Merck
  • Cyanuric chloride catalyzed mild protocol for synthesis of biologically active dihydro/spiro quinazolinones and quinazolinone-glycoconjugates.

Cyanuric chloride catalyzed mild protocol for synthesis of biologically active dihydro/spiro quinazolinones and quinazolinone-glycoconjugates.

The Journal of organic chemistry (2011-12-21)
Moni Sharma, Shashi Pandey, Kuldeep Chauhan, Deepty Sharma, Brijesh Kumar, Prem M S Chauhan
摘要

We have developed an efficient cyanuric chloride (2,4,6-trichloro-1,3,5-triazine, TCT) catalyzed approach for the synthesis of 2,3-dihydroquinazolin-4(1H)-one (3a-3x), 2-spiroquinazolinone (5, 7), and glycoconjugates of 2,3-dihydroquinazolin-4(1H)-one (10a, 10b) derivatives. The reaction allows rapid cyclization (8-20 min) with 10 mol % cyanuric chloride to give skeletal complexity in good to excellent yield. We believe that this novel procedure may open the door for the easy generation of new and bioactive quinazolinones.

材料
產品編號
品牌
產品描述

Sigma-Aldrich
三聚氯氰, 99%
Sigma-Aldrich
2-氨基苯甲酰胺, ≥98%