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Merck
  • EP1572: a novel peptido-mimetic GH secretagogue with potent and selective GH-releasing activity in man.

EP1572: a novel peptido-mimetic GH secretagogue with potent and selective GH-releasing activity in man.

Journal of endocrinological investigation (2002-09-21)
F Broglio, F Boutignon, A Benso, C Gottero, F Prodam, E Arvat, C Ghè, F Catapano, A Torsello, V Locatelli, G Muccioli, D Boeglin, V Guerlavais, J A Fehrentz, J Martinez, E Ghigo, R Deghenghi
PMID12240910
摘要

EP1572 UMV1843 [Aib-DTrp-DgTrp-CHO]) is a new peptido-mimetic GH secretagogue (GHS) showing binding potency to the GHS-receptor in animal and human tissues similar to that of ghrelin and peptidyl GHS. EP1572 induces marked GH increase after s.c. administration in neonatal rats. Preliminary data in 2 normal young men show that: 1) acute i.v. EP1572 administration (1.0 microg/kg) induces strong and selective increase of GH levels; 2) single oral EP1572 administration strongly and reproducibly increases GH levels even after a dose as low as 0.06 mg/kg. Thus, EP1572 is a new peptido-mimetic GHS with potent and selective GH-releasing activity.