LNC01296 regulates apoptosis genes Birc2 and Bak1 by targeting miRNA-29c and participates in neuroprotection during cerebral ischemia-reperfusion injury in rats.

To explore the extent to which LNC01296 inhibits the miRNA-29c expansion genes Birc2 and Bak1 from causing damage induced by brain expansion and reimplantation. A total of 120 adult male experimental rats were divided to verify the effects of miRNA-29c and LNC01296 on brain expansion/reimplantation injury. miRNA-29c can inhibit the Birc2/Bak1 pathway and aggravate the brain expansion/reimplantation damage. LNC01296 blocks miRNA-29c from entering the brain to protect it from expansion after reimplantation. Our findings show that LINC01296 can alleviate the injury induced by cerebral ischemia and reimplantation by preventing the inhibitory effect of miR-29c on Birc2 and Bak1. Our research also provides new strategies and goals for the clinical treatment of patients with cerebral ischemia-reperfusion.