- Bioactive myrsinol diterpenoids from the roots of Euphorbia prolifera.
Bioactive myrsinol diterpenoids from the roots of Euphorbia prolifera.
Journal of natural products (2011-09-21)
Jing Xu, Yuanqiang Guo, Chunfeng Xie, Yushan Li, Jie Gao, Tiejun Zhang, Wenbin Hou, Lingzhi Fang, Liping Gui
PMID21928782
摘要
Ten myrsinol diterpenes, euphorbiaproliferins A-J (1-10), along with nine known analogues (11-19) were isolated from the roots of Euphorbia prolifera. Their structures were elucidated by spectroscopic data analysis (IR, ESIMS, HRESIMS, 1D and 2D NMR), and the structure of 1 was confirmed by X-ray crystallography. The diterpenes showed neuroprotective effects against MPP+-induced neuronal cell death in SH-SY5Y cells.