- Synthesis and antimicrobial activity of 2-substituted [4-(1,3,4-oxadiazol-2-yl methyl)] phthalazin-1(2H)-one derivatives.
Synthesis and antimicrobial activity of 2-substituted [4-(1,3,4-oxadiazol-2-yl methyl)] phthalazin-1(2H)-one derivatives.
European journal of medicinal chemistry (2010-09-04)
Ajjanna M Sridhara, Kallam R Venugopala Reddy, Jathi Keshavayya, Palusa Sanath Kumar Goud, Bankavadi C Somashekar, Prosenjit Bose, Sanenahalli K Peethambar, Satish Kumar Gaddam
PMID20813436
摘要
A series of new 2-substituted [4-(1,3,4-oxadiazol-2-yl)methyl]phthalazin-1(2H)-one derivatives 7a-h to 9a-h were designed and synthesized from methyl (4-oxo-3,4-dihydrophthalazin-1-yl)acetate (4), which in was turn prepared from phthalic anhydride. The structure of synthesized new compounds were characterized by spectral data and screened for their antimicrobial activities against various bacteria and fungi strains. Several of these compounds showed antimicrobial activity.
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