- Design and synthesis of beta-methoxyacrylate analogues via click chemistry and biological evaluations.
Design and synthesis of beta-methoxyacrylate analogues via click chemistry and biological evaluations.
Bioorganic & medicinal chemistry letters (2007-02-16)
Hao Chen, Janet L Taylor, Suzanne R Abrams
PMID17300931
摘要
A library of potential antifungal triazole-modified beta-methoxyacrylate analogues was designed and synthesized via a Cu(I)-catalyzed 1,3-dipolar alkyne-azide coupling reaction or 'click chemistry'. Subsequent biological screening revealed that some compounds displayed low to moderate antifungal activity toward pathogenic fungi and low phytotoxicity.