Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese.

Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese.

Nature genetics (2012-03-01)

Shusuke Akamatsu, Ryo Takata, Christopher A Haiman, Atsushi Takahashi, Takahiro Inoue, Michiaki Kubo, Mutsuo Furihata, Naoyuki Kamatani, Johji Inazawa, Gary K Chen, Loïc Le Marchand, Laurence N Kolonel, Takahiko Katoh, Yuko Yamano, Minoru Yamakado, Hiroyuki Takahashi, Hiroki Yamada, Shin Egawa, Tomoaki Fujioka, Brian E Henderson, Tomonori Habuchi, Osamu Ogawa, Yusuke Nakamura, Hidewaki Nakagawa

PMID22366784

摘要

We have previously reported multiple loci associated with prostate cancer susceptibility in a Japanese population using a genome-wide association study (GWAS). To identify additional prostate cancer susceptibility loci, we genotyped nine SNPs that were nominally associated with prostate cancer (P < 1 × 10(-4)) in our previous GWAS in three independent studies of prostate cancer in Japanese men (2,557 individuals with prostate cancer (cases) and 3,003 controls). In a meta-analysis of our previous GWAS and the replication studies, which included a total of 7,141 prostate cancer cases and 11,804 controls from a single ancestry group, three new loci reached genome-wide significance on chromosomes 11q12 (rs1938781; P = 1.10 × 10(-10); FAM111A-FAM111B), 10q26 (rs2252004; P = 1.98 × 10(-8)) and 3p11.2 (rs2055109; P = 3.94 × 10(-8)). We also found suggestive evidence of association at a previously reported prostate cancer susceptibility locus at 2p11 (rs2028898; P = 1.08 × 10(-7)). The identification of three new susceptibility loci should provide additional insight into the pathogenesis of prostate cancer and emphasizes the importance of conducting GWAS in diverse populations.