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一般說明
Diacylglycerol kinase zeta ζ (DGKZ) belongs to the diacylglycerol kinase family. It is expressed in the central nervous system and comprises a nuclear localization signal, ankyrin repeats, and a PDZ-binding motif. DGKZ gene is localized on human chromosome 11p11.2.
免疫原
DGKZ (NP_963290, 994-1029)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human DGKZ.
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human DGKZ.
生化／生理作用
Diacylglycerol kinase zeta ζ (DGKZ) plays a key role in brain development. It mediates the conversion of diacylglycerol to phosphatidic acid. Elevated DGKZ levels is observed in human metastatic colon cancer. DGKZ protein defects are implicated in osteogenesis imperfecta (OI) leading to a phenotype characterized by fractures in utero and after birth, callus formation, and beaded ribs. DGKZ also regulates bone homeostasis. Knockdown of the DGKζ gene leads to cell cycle arrest and apoptosis in glioma cells.
外觀
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
從最近期的版本中選擇一個：
Somayeh Alinaghi et al.
Molecular biology reports, 46(4), 4105-4111 (2019-05-16)
Schizophrenia (SCZ) is a disabling and severe mental illness characterized by abnormal social behavior and disrupted emotions. Similar to other neuropsychological disorders, both genetics and environmental factors interplay so as to develop SCZ. It is acknowledged that genes such as
Wenxi Yu et al.
Frontiers in oncology, 8, 655-655 (2019-01-22)
Osteosarcoma (OS) is one of the most common primary bone tumors in children and young adults. The majority of osteosarcoma patients have limited alternative therapeutic options and metastatic patients generally have a poor prognosis. Thus, it is important to explore
Jinfu Diao et al.
Molecular neurobiology, 53(8), 5425-5435 (2015-10-11)
Diacylglycerol kinases ζ (DGKζ) is a critical lipid kinase which is involved in phosphatidic acid (PA) generation via diacylglycerol (DAG) phosphorylation. DGKζ is highly expressed in central nervous system and essential for brain development. Studies have indicated that DGKζ is
Gang Liu et al.
Journal of spine surgery (Hong Kong), 3(4), 666-678 (2018-01-23)
Osteogenesis imperfecta (OI) is a kind of heritable connective tissue disorder, including blue sclerae, hearing loss, skeletal dysplasia causing bone fragility and deformities. It is typically caused by collagen related gene mutations, which could lead to bone formation abnormalities. Scoliosis
Severine I Gharbi et al.
Molecular biology of the cell, 22(22), 4406-4414 (2011-09-23)
Diacylglycerol (DAG) generation at the T cell immunological synapse (IS) determines the correct activation of antigen-specific immune responses. DAG kinases (DGKs) α and ζ act as negative regulators of DAG-mediated signals by catalyzing DAG conversion to phosphatidic acid (PA). Nonetheless
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