HPA023369

Anti-FAM83G antibody produced in rabbit

Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab1

• 同義詞: Anti-FLJ41564, Anti-PAWS1
• 分類程式碼代碼: 12352203
• 人類蛋白質圖譜編號: HPA023369
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 100
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 產品線: Prestige Antibodies^® Powered by Atlas Antibodies
• 形狀: buffered aqueous glycerol solution
• 物種活性: human
• 加強驗證: orthogonal RNAseq; Learn more about Antibody Enhanced Validation

描述

一般說明

The gene FAM83G (family with sequence similarity 83 member G), also referred to as PAWS1 (protein associated with SMAD1), is found to be conserved across vertebrates and is a member of a family of hypothetical proteins, FAM83A–H. These proteins contain a conserved N-terminal domain called DUF1669, whose function is yet to be determined. This domain contains a putative pseudo-phospholipase D motif.

免疫原

Protein FAM83G recombinant protein epitope signature tag (PrEST)

應用

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

生化／生理作用

The gene FAM83G (family with sequence similarity 83 member G) encodes a protein that interacts with SMAD1 (similar to mothers against decapentaplegic 1). Independent of SMAD4, the encoded protein forms a complex with SMAD1 and forms a substrate for type I BMP (bone morphogenetic protein) receptor kinases. PAWS1 also forms a substrate for ALK3 (aurora-like kinase ), a type IA BMP receptor, and its phosphorylation is induced by BMPs. Phosphorylated PAWS1 regulates the expression of NEDD9 (neural precursor cell expressed, developmentally down-regulated 9 ) and ASNS (asparagine synthetase), which are SMAD4-independent BMP target genes. It also regulates the expression of several genes independent of BMP stimulation. PAWS1 is involved in the regulation of BMP pathway.

特點和優勢

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

聯結

Corresponding Antigen APREST75957

外觀

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

法律資訊

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable