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T0273

Sigma-Aldrich

N-p-Tosyl-Gly-Pro-Arg 7-氨基-4-甲基香豆素 盐酸盐

protease substrate

同義詞:

N-(p-Tosyl)-Gly-Pro-Arg-AMC, Tos-Gly-Pro-Arg-AMC

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About This Item

經驗公式（希爾表示法）:
C30H37N7O7S · HCl
CAS號碼:
117961-27-0
分子量：:
676.18
MDL號碼:
MFCD00152182
分類程式碼代碼:
12352204
PubChem物質ID:
24899877
NACRES:
NA.32

品質等級

200

化驗

≥98% (TLC)

形狀

powder

溶解度

acetic acid: 10 mg/mL, clear, colorless

儲存溫度

−20°C

SMILES 字串

Cl.Cc1ccc(cc1)S(=O)(=O)NCC(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(N)=N)C(=O)Nc3ccc4C(C)=CC(=O)Oc4c3

InChI

1S/C30H37N7O7S.ClH/c1-18-7-10-21(11-8-18)45(42,43)34-17-26(38)37-14-4-6-24(37)29(41)36-23(5-3-13-33-30(31)32)28(40)35-20-9-12-22-19(2)15-27(39)44-25(22)16-20;/h7-12,15-16,23-24,34H,3-6,13-14,17H2,1-2H3,(H,35,40)(H,36,41)(H4,31,32,33);1H/t23-,24-;/m0./s1

InChI 密鑰

SRRKKDQGNHCPIE-UKOKCHKQSA-N

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析證明 (COA)

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V A Kuznetsov et al.
Laboratornoe delo, (8)(8), 43-45 (1990-01-01)
Toz-Gly-Pro-Arg-4-methylcoumaryl-7-amide is recommended for antithrombin-III (AT-III) photometry as a substrate. This substrate is cleaved by thrombin at 366 nm. AT-III photometry with this substrate is in accord with the requirements to methods used in clinical laboratory diagnosis, and the results
Efrat Shavit-Stein et al.
Frontiers in neurology, 9, 1139-1139 (2019-01-22)
Thrombin and its protease-activated receptor 1 (PAR1) are potentially important in peripheral nerve inflammatory diseases. We studied the role of thrombin and PAR1 in rat experimental autoimmune neuritis (EAN), a model of the human Guillain-Barré syndrome (GBS). EAN was induced
A Pasternak et al.
Biochemistry, 37(46), 16201-16210 (1998-11-18)
The zymogen and mature enzyme forms of trypsin-like serine proteases exhibit a wide range of activities. The prototypical trypsinogen-trypsin system is an example of a minimally active zymogen and a maximally active mature protease. The present work identifies several features
Efrat Shavit-Stein et al.
PloS one, 14(7), e0219453-e0219453 (2019-07-06)
Diabetic neuropathy is common and disabling despite glycemic control. Novel neuroprotective approaches are needed. Thrombin and hypercoagulability are associated with diabetes and nerve conduction dysfunction. Our aim was to study the role of thrombin in diabetic neuropathy. We measured thrombin

條款

Thrombin from Bovine Plasma

Thrombin is an endolytic serine protease that selectively cleaves the Arg–Gly bonds of fibrinogen to form fibrin and release fibrinopeptides A and B.

來自牛血漿的凝血酶原

凝血酶是一種內溶性絲氨酸蛋白酶，可選擇性地裂解纖維蛋白原的 Arg-Gly 鍵，形成纖維蛋白並釋放出纖維蛋白肽 A 和 B。

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