TNNT3
troponin T type 3 (skeletal, fast)
同義詞:
TNTF
物種:
Human TNNT3 (7140), Mouse Tnnt3 (21957), Rat Tnnt3 (24838), domestic guinea pig Tnnt3 (100734707), Goat TNNT3 (100861247), dog TNNT3 (475996), Domestic Rabbit TNNT3 (100009527), cow TNNT3 (282096), naked mole-rat Tnnt3 (101718573), sheep TNNT3 (101104467) ...更多
UniProtKB ID:
基因 ID:
- Human(7140) Summary: The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B). [provided by RefSeq, Oct 2009]
- Mouse(21957) troponin T3, skeletal, fast
- Rat(24838) troponin T type 3 (skeletal, fast)
- domestic guinea pig(100734707) troponin T type 3 (skeletal, fast)
- Goat(100861247) troponin T type 3 (skeletal, fast)
- dog(475996) troponin T type 3 (skeletal, fast)
- Domestic Rabbit(100009527) troponin T type 3 (skeletal, fast)
- cow(282096) troponin T type 3 (skeletal, fast)
- naked mole-rat(101718573) troponin T type 3 (skeletal, fast)
- sheep(101104467) troponin T type 3 (skeletal, fast)
- domestic cat(101091149) troponin T type 3 (skeletal, fast)
- chicken(395761) troponin T type 3 (skeletal, fast)
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Antibodies
產品編號
描述
物種活性
應用
单克隆抗肌钙蛋白 T 小鼠抗, clone JLT-12, ascites fluid,
物種活性
bovine, chicken, rabbit, rat
應用
immunohistochemistry
western blot
western blot