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Merck

TEK

TEK tyrosine kinase, endothelial

同義詞:
CD202B, TIE-2, TIE2, VMCM, VMCM1
物種:
Human TEK (7010), Mouse Tek (21687), Rat Tek (89804), chicken TEK (427368), Zebrafish tek (30747), dog TEK (403714), domestic cat TEK (101091977), cow TEK (280939), domestic guinea pig Tek (100713324), naked mole-rat Tek (101710501)
UniProtKB ID:
Q02763, A8K6W0, B4DH20, B4DHD3, D3DRK5, E7EWI2, Q5TCU2, Q8IV34
基因 ID:
  • Human(7010) Summary: The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase. [provided by RefSeq, Jul 2008]
  • Mouse(21687) endothelial-specific receptor tyrosine kinase
  • Rat(89804) TEK tyrosine kinase, endothelial
  • chicken(427368) TEK tyrosine kinase, endothelial
  • Zebrafish(30747) TEK tyrosine kinase, endothelial
  • dog(403714) TEK tyrosine kinase, endothelial
  • domestic cat(101091977) TEK tyrosine kinase, endothelial
  • cow(280939) TEK tyrosine kinase, endothelial
  • domestic guinea pig(100713324) TEK tyrosine kinase, endothelial
  • naked mole-rat(101710501) TEK tyrosine kinase, endothelial

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Antibodies

產品編號
描述
物種活性
應用
05-584
抗-Tie2/TEK抗体，克隆Ab33, clone Ab33, Upstate®, from mouse,
物種活性
human, mouse, pig, rat
應用
immunohistochemistry
immunoprecipitation (IP)
western blot
SAB4503999
抗-磷酸-TIE2 (pTyr1108) 兔抗, affinity isolated antibody,
物種活性
human, mouse, rat
應用
ELISA
immunofluorescence
western blot
ABF131
Anti-phospho TIE2/TEK Antibody (Tyr992), 0.25 mg/mL, from rabbit,
物種活性
bovine, human, mouse, rat, zebrafish
應用
immunoprecipitation (IP)
inhibition assay
western blot
SAB4502942
Anti-TIE2, C-Terminal antibody produced in rabbit, affinity isolated antibody,
物種活性
human, mouse
應用
ELISA
immunohistochemistry
SAB4301315
Anti-phospho-TIE2 (pTyr992) antibody produced in rabbit, affinity isolated antibody,
物種活性
human
應用
western blot

Small Molecule - Inhibitor

產品編號
描述
物種
C8863
7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3‑d]pyrimidin-4-ylamine, ≥98% (HPLC),
物種
human

Proteins

產品編號
描述
物種
14-763-M
Tie2 (R849W) Protein, active, 250 µg, ,
物種
human
14-764-M
Tie2 (Y897S) Protein, active, ,
物種
human
14-540-M
Tie2 Protein, active, 10 µg, Active, N-terminal His6-tagged recombinant human Tie2 residues 771-end, for use in Kinase Assays.,
物種
human
14-763
Tie2 (R849W) Protein, active, 10 µg, ,
物種
human