PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
同義詞:
PP2C-ALPHA, PP2CA, PP2Calpha
物種:
Human PPM1A (5494), Mouse Ppm1a (19042), Rat Ppm1a (24666), Domestic Rabbit PPM1A (100009431), domestic cat PPM1A (101101571), naked mole-rat Ppm1a (101720711), sheep PPM1A (101103650), domestic guinea pig Ppm1a (100734826), cow PPM1A (281994), dog PPM1A (480344)
UniProtKB ID:
基因 ID:
- Human(5494) Summary: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
- Mouse(19042) protein phosphatase 1A, magnesium dependent, alpha isoform
- Rat(24666) protein phosphatase, Mg2+/Mn2+ dependent, 1A
- Domestic Rabbit(100009431) protein phosphatase, Mg2+/Mn2+ dependent, 1A
- domestic cat(101101571) protein phosphatase, Mg2+/Mn2+ dependent, 1A
- naked mole-rat(101720711) protein phosphatase, Mg2+/Mn2+ dependent, 1A
- sheep(101103650) protein phosphatase, Mg2+/Mn2+ dependent, 1A
- domestic guinea pig(100734826) protein phosphatase, Mg2+/Mn2+ dependent, 1A
- cow(281994) protein phosphatase, Mg2+/Mn2+ dependent, 1A
- dog(480344) protein phosphatase, Mg2+/Mn2+ dependent, 1A
- chicken(423525) protein phosphatase, Mg2+/Mn2+ dependent, 1A
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