PCDHA1
protocadherin alpha 1
同義詞:
PCDH-ALPHA1
物種:
Human PCDHA1 (56147), Mouse Pcdha1 (116731), Rat Pcdha1 (393085), domestic cat PCDHA1 (101092233), chicken PCDHA1 (497211), cow PCDHA1 (100847114), sheep PCDHA1 (101122108), domestic guinea pig Pcdha1 (100712773), naked mole-rat Pcdha1 (101724810)
UniProtKB ID:
基因 ID:
- Human(56147) Summary: This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]
- Mouse(116731) protocadherin alpha 1
- Rat(393085) protocadherin alpha 1
- domestic cat(101092233) protocadherin alpha 1
- chicken(497211) protocadherin alpha 1
- cow(100847114) protocadherin alpha 1
- sheep(101122108) protocadherin alpha 1
- domestic guinea pig(100712773) protocadherin alpha 1
- naked mole-rat(101724810) protocadherin alpha 1
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