NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
同義詞:
EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50
物種:
Human NFKB1 (4790), Mouse Nfkb1 (18033), Rat Nfkb1 (81736), naked mole-rat Nfkb1 (101696485), sheep NFKB1 (101108228), cow NFKB1 (616115), dog NFKB1 (442859), domestic cat NFKB1 (100142683), Zebrafish nfkb1 (565756), chicken NFKB1 (396033)
UniProtKB ID:
基因 ID:
- Human(4790) Summary: This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
- Mouse(18033) nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
- Rat(81736) nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
- naked mole-rat(101696485) nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
- sheep(101108228) nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
- cow(616115) nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
- dog(442859) nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
- domestic cat(100142683) nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
- Zebrafish(565756) nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
- chicken(396033) nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
- domestic guinea pig(100730075) nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
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Small Molecule - Antagonist
Antibodies
產品編號
描述
物種活性
應用
抗-NFκB p50 抗体, from rabbit, purified by affinity chromatography,
物種活性
human, rhesus macaque
應用
immunoprecipitation (IP)
western blot
western blot
抗NF κ B抗体，p65亚基，活性亚基，克隆12H11, clone 12H11, Chemicon®, from mouse,
物種活性
human, mouse, rabbit, rat
應用
electrophoretic mobility shift assay
flow cytometry
immunocytochemistry
immunofluorescence
immunohistochemistry
western blot
flow cytometry
immunocytochemistry
immunofluorescence
immunohistochemistry
western blot
抗NF κ B p65抗体，CT, Upstate®, from rabbit,
物種活性
human, mouse, rat
應用
electrophoretic mobility shift assay
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-NFKB p65 antibody, Rabbit monoclonal, recombinant, expressed in HEK 293 cells, clone RM273, purified immunoglobulin,
物種活性
human
應用
immunohistochemistry
western blot
western blot
Anti-NFKB1 (Ab-337) antibody produced in rabbit, affinity isolated antibody,
物種活性
human, mouse, rat
應用
immunohistochemistry
western blot
western blot
Small Molecule - Blocker
Small Molecule - Inhibitor
Proteins
esiRNA
產品編號
描述
物種