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Merck

NEDD4L

neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase

同義詞:
NEDD4-2, NEDD4.2, RSP5, hNEDD4-2
物種:
Human NEDD4L (23327), Mouse Nedd4l (83814), Rat Nedd4l (291553), sheep NEDD4L (101122748), Zebrafish nedd4l (559634), domestic guinea pig Nedd4l (100301562), domestic cat NEDD4L (101088369), Horse NEDD4L (100054395), Domestic Rabbit NEDD4L (100353099), cow NEDD4L (510003) ...更多
UniProtKB ID:
Q96PU5, O43165, Q3LSM7, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9
基因 ID:
  • Human(23327) Summary: This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
  • Mouse(83814) neural precursor cell expressed, developmentally down-regulated gene 4-like
  • Rat(291553) neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
  • sheep(101122748) neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
  • Zebrafish(559634) neural precursor cell expressed, developmentally down-regulated 4-like
  • domestic guinea pig(100301562) neural precursor cell expressed, developmentally down-regulated gene 4-like
  • domestic cat(101088369) neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
  • Horse(100054395) neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
  • Domestic Rabbit(100353099) neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
  • cow(510003) neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
  • dog(476189) neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
  • naked mole-rat(101715398) neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
  • chicken(374119) neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase

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Antibodies

產品編號
描述
物種活性
應用
WH0023327M4
Monoclonal Anti-NEDD4L antibody produced in mouse, clone 1D2, purified immunoglobulin, buffered aqueous solution,
物種活性
human
應用
ELISA
immunoprecipitation (IP)
western blot
SAB2103801
Anti-NEDD4L antibody produced in rabbit, affinity isolated antibody,
物種活性
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
應用
western blot