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Merck

MAPK14

mitogen-activated protein kinase 14

同義詞:
CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA
物種:
UniProtKB ID:
基因 ID:
  • Human(1432) Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
  • Mouse(26416) mitogen-activated protein kinase 14
  • Rat(81649) mitogen activated protein kinase 14
  • naked mole-rat(101715692) mitogen-activated protein kinase 14
  • domestic guinea pig(100723285) mitogen-activated protein kinase 14
  • chicken(421183) mitogen-activated protein kinase 14
  • Horse(100063532) mitogen-activated protein kinase 14
  • dog(403856) mitogen-activated protein kinase 14
  • domestic cat(101101135) mitogen-activated protein kinase 14
  • Domestic Rabbit(100341695) mitogen-activated protein kinase 14
  • sheep(100217411) mitogen-activated protein kinase 14
  • cow(534492) mitogen-activated protein kinase 14

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ELISA

產品編號
描述
物種
Cell-Based ELISA Sampler Kit for detecting phospho-ERK1/2 (pThr202/pTyr204), phospho-JNK (pThr183/pTyr185), and phospho-p38 MAPK (pThr180/pTyr182) in cultured cell lines, 192 assays,
物種
rat, human, mouse

Antibodies

產品編號
描述
物種活性
應用
Anti-p38 MAPK antibody produced in rabbit, affinity isolated antibody,
物種活性
human, mouse, rat
應用
ELISA
western blot
抗磷酸化p38 α(Thr180 / Tyr182)抗体, Upstate®, from rabbit,
物種活性
human, mouse, rat
應用
immunoprecipitation (IP)
western blot
Anti-p38 MAPK antibody produced in rabbit, affinity isolated antibody,
物種活性
human, mouse, rat
應用
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-phospho-p38 (Thr180/Tyr182) Antibody, clone 6E5.2, clone 6E5.2, from mouse,
物種活性
human, mouse
應用
immunocytochemistry
western blot
Anti-p38 MAPK antibody produced in rabbit, affinity isolated antibody,
物種活性
human, mouse, rat
應用
ELISA
immunohistochemistry

Small Molecule - Inhibitor

產品編號
描述
物種
PD 169316, ≥98% (HPLC), solid,
物種
human
2-氨基-3-苄氧基吡啶, 99%,
物種
human
TAK-715, ≥98% (HPLC),
物種
human
(S)-(+)-6-甲氧基-α-甲基-2-萘乙酸, 98%,
物種
human, rat
萘普生, meets USP testing specifications,
物種
human, rat

Proteins

產品編號
描述
物種
p38α/SAPK2a Protein, active, 10 µg, Active, N-terminal GST tagged, recombinant, full length p38α/SAPK2a, for use in Kinase Assays.,
物種
human
p38α, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
物種
human
p38α/SAPK2a (T106M) Protein, active, 10 µg, Active, N-terminal GST-tagged, recombinant, human, full-length p38α/SAPK2a containing the mutation T106M. Activated using DD-MKK6 & repurified using glutathione-agarose. For use in Kinase Assays.,
物種
human
p38α/SAPK2a (6His-tag) Protein, unactive, 50 µg, ,
物種
human