GCH1
GTP cyclohydrolase 1
同義詞:
DYT14, DYT5, DYT5a, GCH, GTP-CH-1, GTPCH1, HPABH4B
物種:
Human GCH1 (2643), Mouse Gch1 (14528), Rat Gch1 (29244), Zebrafish gch1 (100192219), sheep GCH1 (101112987), domestic guinea pig Gch1 (100735198), naked mole-rat Gch1 (101706667), Domestic Rabbit GCH1 (100286831), cow GCH1 (286815), sheep GCH1 (100303455) ...更多
UniProtKB ID:
基因 ID:
- Human(2643) Summary: This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme. [provided by RefSeq, Jul 2008]
- Mouse(14528) GTP cyclohydrolase 1
- Rat(29244) GTP cyclohydrolase 1
- Zebrafish(100192219) GTP cyclohydrolase 1
- sheep(101112987) GTP cyclohydrolase 1
- domestic guinea pig(100735198) GTP cyclohydrolase 1
- naked mole-rat(101706667) GTP cyclohydrolase 1
- Domestic Rabbit(100286831) GTP cyclohydrolase 1
- cow(286815) GTP cyclohydrolase 1
- sheep(100303455) GTP cyclohydrolase 1
- dog(609393) GTP cyclohydrolase 1
- domestic cat(101092120) GTP cyclohydrolase 1
- chicken(396146) GTP cyclohydrolase 1
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
產品編號
描述
物種活性
應用
Monoclonal Anti-GCH1 antibody produced in mouse, clone 4A12, purified immunoglobulin, buffered aqueous solution,
物種活性
human
應用
ELISA
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Anti-GCH1 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
物種活性
human
應用
western blot
Anti-GCH1 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
物種活性
human
應用
ELISA
immunohistochemistry
immunohistochemistry