FBXW4
F-box and WD repeat domain containing 4
同義詞:
DAC, FBW4, FBWD4, SHFM3, SHSF3
物種:
Human FBXW4 (6468), Mouse Fbxw4 (30838), Rat Fbxw4 (309444), domestic guinea pig Fbxw4 (100721914), naked mole-rat Fbxw4 (101698837), Zebrafish fbxw4 (58035), sheep FBXW4 (101113450), chicken FBXW4 (770459), dog FBXW4 (486852), domestic cat FBXW4 (101084392)
UniProtKB ID:
基因 ID:
- Human(6468) Summary: This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22. [provided by RefSeq, Jul 2008]
- Mouse(30838) F-box and WD-40 domain protein 4
- Rat(309444) F-box and WD repeat domain containing 4
- domestic guinea pig(100721914) F-box and WD repeat domain containing 4
- naked mole-rat(101698837) F-box and WD repeat domain containing 4
- Zebrafish(58035) F-box and WD-40 domain protein 4
- sheep(101113450) F-box and WD repeat domain containing 4
- chicken(770459) F-box and WD repeat domain containing 4
- dog(486852) F-box and WD repeat domain containing 4
- domestic cat(101084392) F-box and WD repeat domain containing 4
- cow(513977) F-box and WD repeat domain containing 4
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Antibodies
產品編號
描述
物種活性
應用
Anti-FBXW4 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
物種活性
human
應用
western blot