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Merck

CDK8

cyclin-dependent kinase 8

同義詞:
K35
物種:
UniProtKB ID:
基因 ID:
  • Human(1024) Summary: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery. [provided by RefSeq, Jul 2008]
  • Mouse(264064) cyclin-dependent kinase 8
  • domestic guinea pig(100718250) cyclin-dependent kinase 8
  • naked mole-rat(101719987) cyclin-dependent kinase 8
  • sheep(101115551) cyclin-dependent kinase 8
  • Domestic Rabbit(100353845) cyclin-dependent kinase 8
  • domestic cat(101086278) cyclin-dependent kinase 8
  • Zebrafish(373868) cyclin-dependent kinase 8
  • cow(507149) cyclin-dependent kinase 8
  • dog(486035) cyclin-dependent kinase 8
  • chicken(428080) cyclin-dependent kinase 8
  • Horse(100050819) cyclin-dependent kinase 8
  • fruit fly(39157) Cyclin-dependent kinase 8

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Antibodies

產品編號
描述
物種活性
應用
ANTI-CDK8 antibody produced in mouse, clone 5H4, purified immunoglobulin, buffered aqueous solution,
物種活性
human
應用
ELISA
western blot
Anti-CDK8, affinity isolated antibody,
物種活性
human, mouse
應用
immunohistochemistry

Small Molecule - Inhibitor

產品編號
描述
物種
奥罗莫星, ≥98% (HPLC),
物種
human, rat