ALK
anaplastic lymphoma receptor tyrosine kinase
同義詞:
CD246, NBLST3
物種:
Human ALK (238), Mouse Alk (11682), Rat Alk (266802), fruit fly Alk (53425), Zebrafish alk (563509), chicken ALK (421297), domestic cat ALK (101091689), dog ALK (483021), Horse ALK (100070891), sheep ALK (101114094) ...更多
UniProtKB ID:
基因 ID:
- Human(238) Summary: This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]
- Mouse(11682) anaplastic lymphoma kinase
- Rat(266802) anaplastic lymphoma receptor tyrosine kinase
- fruit fly(53425) CG8250 gene product from transcript CG8250-RB
- Zebrafish(563509) anaplastic lymphoma kinase (Ki-1)
- chicken(421297) anaplastic lymphoma receptor tyrosine kinase
- domestic cat(101091689) anaplastic lymphoma receptor tyrosine kinase
- dog(483021) anaplastic lymphoma receptor tyrosine kinase
- Horse(100070891) anaplastic lymphoma receptor tyrosine kinase
- sheep(101114094) anaplastic lymphoma receptor tyrosine kinase
- domestic guinea pig(100732585) anaplastic lymphoma receptor tyrosine kinase
- naked mole-rat(101703312) anaplastic lymphoma receptor tyrosine kinase
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Antibodies
產品編號
描述
物種活性
應用
Anti-phospho-ALK (pTyr1604) antibody produced in rabbit, affinity isolated antibody,
物種活性
human, mouse, rat
應用
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-ALK antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物種活性
human
應用
immunofluorescence
immunohistochemistry
immunohistochemistry
Small Molecule - Inhibitor
產品編號
描述
物種