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Merck


We can synthesize custom siRNA for duplexing using your sequences or sequences we have bioinformatically designed for you. We can also add a variety of chemical modifications tailored to your needs. All siRNAs are analyzed by mass spec prior to release.

Product Benefits

  • Complimentary designs with the Rosetta algorithm*
  • Simplified transfection optimization with 11 Positive Control siRNA
  • Distinguish sequence-specific silencing from non–specific effects with 8 negative control siRNA
  • Custom services allow for flexibility in experimental set up

*The proprietary Rosetta siRNA Design Algorithm utilizes Position-Specific Scoring Matrices and knowledge of the seed region to predict the most specific and effective sequences for your target genes. The algorithm’s rules were developed utilizing empirical data collected from gene silencing experiments carried out over three years.

Custom siRNA Design Request

Custom siRNA Duplex Specifications

**Depending on manufacturing site, PAGE may be used to assess siRNA duplexes

siRNA Duplex Pools***

A popular pooled format is 4 duplexes at 5 nmol each combined into one tube (20 nmol pooled) plus the exact same 4 duplexes also at 5 nmol each in separate tubes (another 20 nmol individual). However, our sophisticated liquid handlers allow for a wide range of other possibilities.

For anything marked as ‘Inquire’ or if you have needs that are different from the other general specifications presented, please send a request to sirnarequest@milliporesigma.com.

MISSION is a trademark of Merck KGaA, Darmstadt, Germany and/or its affiliates. Label License.

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