Efficient metal-free synthesis of various pyrido[2',1':2,3]imidazo- [4,5-b]quinolines.

Efficient metal-free synthesis of various pyrido[2',1':2,3]imidazo- [4,5-b]quinolines.

Chemistry (Weinheim an der Bergstrasse, Germany) (2013-08-21)

Mathieu Arnould, Marie-Aude Hiebel, Stéphane Massip, Jean Michel Léger, Christian Jarry, Sabine Berteina-Raboin, Gérald Guillaumet

PMID23955568

ABSTRACT

Dancing with diversity: The synthesis of diverse pyrido[2',1':2,3]imidazo[4,5-b]quinolines bearing several substitution patterns was developed based on combining a multicomponent reaction (Groebke-Blackburn-Bienaymé reaction) with an original cyclization as a secondary transformation (see scheme; DBU = 1,8-diazabicyclo[5.4.0]undec-7-ene).

MATERIALS

Product Number

Brand

Product Description

33482

Sigma-Aldrich

1,8-Diazabicyclo[5.4.0]undec-7-ene, puriss., ≥99.0% (GC)

139009

Sigma-Aldrich

1,8-Diazabicyclo[5.4.0]undec-7-ene, 98%

714852

Sigma-Aldrich

1,8-Diazabicyclo[5.4.0]undec-7-ene solution, 1 M in THF