- Poly (dextrogyr-levogyr) lactide acid-triiodothyronine scaffold for peripheral nerve regeneration.
Poly (dextrogyr-levogyr) lactide acid-triiodothyronine scaffold for peripheral nerve regeneration.
Neuro endocrinology letters (2013-03-26)
Min Wang, Chao Liu, Yong Hao, Yuan Zhang, Xia Zhang
PMID23524626
ABSTRACT
To evaluate the poly(dextrogyr-levogyr) lactide acid-triiodothyronine (PDLLA-T3) seeded with Schwann cells conduit for repairing sciatic nerve defect. The rats were divided into three groups: autologous nerve transplantation (Group A), PDLLA-T3 + Schwann cells (Group B) and PDLLA + Schwann cells (Group C). Myelin sheath thickness was significantly greater in Group A compared with Group B and Group C. The regenerated nerves had nearly normal structure in Group A, and in Groups B and C nerve tissues filled in the anastomotic site and angiogenesis was noted. The mean number of myelinated nerve fibers and neurons in Group B was greater than in Group C. PDLLA-T3 is superior to PDLLA alone for repairing nerve defects.
MATERIALS